Protocadherin Gamma Antibodies

Target Information

The protocadherin gamma gene cluster is one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

Synonyms

3' RACE product; cadherin 20; cadherin 21; cadherin ME3; cadherin ME6; cadherin-20; Cadherin-21; cadherin-like 2; CDH20; CDH21; CDH-GAMMA-A5; FIB2; FIB3; fibroblast cadherin FIB2; fibroblast cadherin FIB3; fibroblast cadherin-2; Fibroblast cadherin-3; KIAA0327; KIAA0588; ME3; ME6; mKIAA0588; mKIAA4054; Pan-Gamma-Protocadherin-A; pc2c; PC43; PC-43; PCDH gamma A; Pcdh13; PCDH2; PCDHGA; PCDHGA1; PCDHGA10; PCDHGA11; PCDHGA12; Pcdhga2; PCDHGA3; Pcdhga4; PCDHGA5; PCDHGA6; PCDHGA7; Pcdhga8; PCDHGA9; PCDH-gamma-A; PCDH-GAMMA-A1; PCDH-gamma-A10; PCDH-GAMMA-A11; PCDH-gamma-A12; PCDH-GAMMA-A2; PCDH-gamma-A3; PCDH-gamma-A4; PCDH-GAMMA-A5; PCDH-gamma-A6; PCDH-GAMMA-A7; PCDH-gamma-A8; PCDH-gamma-A9; PCDH-GAMMA-B1; PCDH-GAMMA-B2; PCDH-gamma-B3; PCDH-GAMMA-B4; PCDH-GAMMA-B5; PCDH-GAMMA-B6; PCDH-gamma-B7; PCDH-GAMMA-C3; PCDH-gamma-C4; PCDH-gamma-C5; Pcdhgb1; PCDHGB2; PCDHGB3; PCDHGB4; PCDHGB5; Pcdhgb6; Pcdhgb7; PCDHGC3; Pcdhgc4; PCDHGC5; protocadherin 13; protocadherin 2; protocadherin 43; protocadherin gamma A12; protocadherin gamma B2; protocadherin gamma B6; protocadherin gamma C-VI; protocadherin gamma subfamily A, 1; protocadherin gamma subfamily A, 10; protocadherin gamma subfamily A, 11; protocadherin gamma subfamily A, 12; protocadherin gamma subfamily A, 2; protocadherin gamma subfamily A, 3; protocadherin gamma subfamily A, 4; protocadherin gamma subfamily A, 5; protocadherin gamma subfamily A, 6; protocadherin gamma subfamily A, 7; protocadherin gamma subfamily A, 8; protocadherin gamma subfamily A, 9; protocadherin gamma subfamily B, 1; protocadherin gamma subfamily B, 1, isoform 2; protocadherin gamma subfamily B, 2; protocadherin gamma subfamily B, 3; protocadherin gamma subfamily B, 4; protocadherin gamma subfamily B, 5; protocadherin gamma subfamily B, 6; protocadherin gamma subfamily B, 7; protocadherin gamma subfamily C, 3; protocadherin gamma subfamily C, 4; protocadherin gamma subfamily C, 5; protocadherin gamma-A1; Protocadherin gamma-A10; protocadherin gamma-A11; Protocadherin gamma-A12; protocadherin gamma-A2; Protocadherin gamma-A3; protocadherin gamma-A4; Protocadherin gamma-A5; protocadherin gamma-A6; Protocadherin gamma-A7; protocadherin gamma-A8; Protocadherin gamma-A9; protocadherin gamma-B1; Protocadherin gamma-B2; protocadherin gamma-B3; Protocadherin gamma-B4; protocadherin gamma-B5; Protocadherin gamma-B6; protocadherin gamma-B7; Protocadherin gamma-C3; protocadherin gamma-C4; Protocadherin gamma-C5; protocadherin-2; Protocadherin-43; UNQ371/PRO707